abstract：:It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult disease. This concept was later broadened to include postnatal events. It is clear that the interaction between genetic predisposition and early life environment...

journal_title：Biological psychiatry

authors： Codagnone MG,Spichak S,O'Mahony SM,O'Leary OF,Clarke G,Stanton C,Dinan TG,Cryan JF

更新日期：2019-01-15 00:00:00

abstract：:The diagnosis of schizophrenia rests on clinical criteria that cannot be assessed in animal models. Together with absence of a clear underlying pathology and understanding of what causes schizophrenia, this has hindered development of informative animal models. However, recent large-scale genomic studies have identifi...

journal_title：Biological psychiatry

authors： Forsingdal A,Jørgensen TN,Olsen L,Werge T,Didriksen M,Nielsen J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Deep brain stimulation (DBS) is an effective treatment for patients with obsessive-compulsive disorder (OCD) that do not respond to conventional therapies. Although the precise mechanism of action of DBS remains unknown, modulation of activity in corticofugal fibers originating in the prefrontal cortex is th...

journal_title：Biological psychiatry

authors： Pinhal CM,van den Boom BJG,Santana-Kragelund F,Fellinger L,Bech P,Hamelink R,Feng G,Willuhn I,Feenstra MGP,Denys D

更新日期：2018-12-15 00:00:00

abstract：BACKGROUND:Volatile interpersonal relationships are a core feature of borderline personality disorder (BPD) and lead to devastating disruption of patients' personal and professional lives. Quantitative models of social decision making and learning hold promise for defining the underlying mechanisms of this problem. In ...

journal_title：Biological psychiatry

authors： Fineberg SK,Leavitt J,Stahl DS,Kronemer S,Landry CD,Alexander-Bloch A,Hunt LT,Corlett PR

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:We previously reported that a single injection of ketamine prior to stress protects against the onset of depressive-like behavior and attenuates learned fear. However, the molecular pathways and brain circuits underlying ketamine-induced stress resilience are still largely unknown. METHODS:Here, we tested w...

journal_title：Biological psychiatry

authors： Mastrodonato A,Martinez R,Pavlova IP,LaGamma CT,Brachman RA,Robison AJ,Denny CA

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:High rates of comorbidity, shared risk, and overlapping therapeutic mechanisms have led psychopathology research toward transdiagnostic dimensional investigations of clustered symptoms. One influential framework accounts for these transdiagnostic phenomena through a single general factor, sometimes referred ...

journal_title：Biological psychiatry

authors： Elliott ML,Romer A,Knodt AR,Hariri AR

更新日期：2018-09-15 00:00:00

abstract：:Tourette syndrome (TS) is thought to involve dopaminergic disturbances, but the nature of those disturbances remains controversial. Existing hypotheses suggest that TS involves 1) supersensitive dopamine receptors, 2) overactive dopamine transporters that cause low tonic but high phasic dopamine, 3) presynaptic dysfun...

journal_title：Biological psychiatry

authors： Maia TV,Conceição VA

更新日期：2018-09-01 00:00:00

abstract：BACKGOUND:Alcohol use disorder (AUD) is devastating and poorly treated, and innovative targets are actively sought for prevention and treatment. The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential rol...

journal_title：Biological psychiatry

authors： Ben Hamida S,Mendonça-Netto S,Arefin TM,Nasseef MT,Boulos LJ,McNicholas M,Ehrlich AT,Clarke E,Moquin L,Gratton A,Darcq E,Harsan LA,Maldonado R,Kieffer BL

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:To explore the domain-general risk factor of early-life social stress in mental illness, rearing rodents in persistent postweaning social isolation has been established as a widely used animal model with translational relevance for neurodevelopmental psychiatric disorders such as schizophrenia. Although chan...

journal_title：Biological psychiatry

authors： Reinwald JR,Becker R,Mallien AS,Falfan-Melgoza C,Sack M,Clemm von Hohenberg C,Braun U,Cosa Linan A,Gass N,Vasilescu AN,Tollens F,Lebhardt P,Pfeiffer N,Inta D,Meyer-Lindenberg A,Gass P,Sartorius A,Weber-Fahr W

更新日期：2018-07-15 00:00:00

abstract：BACKGROUND:Clinical reports suggest that rather than directly driving cocaine use, stress may create a biological context within which other triggers for drug use become more potent. We hypothesize that stress-induced increases in corticosterone "set the stage" for relapse by promoting endocannabinoid-induced attenuati...

journal_title：Biological psychiatry

authors： McReynolds JR,Doncheck EM,Li Y,Vranjkovic O,Graf EN,Ogasawara D,Cravatt BF,Baker DA,Liu QS,Hillard CJ,Mantsch JR

更新日期：2018-07-15 00:00:00

abstract：BACKGROUND:Loss of motivation is a characteristic feature of several psychiatric and neurological disorders. However, the neural mechanisms underlying human motivation are far from being understood. Here, we investigate the role that the frontopolar cortex (FPC) plays in motivating cognitive and physical effort exertio...

journal_title：Biological psychiatry

authors： Soutschek A,Kang P,Ruff CC,Hare TA,Tobler PN

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood. Chronic stress may induce recalibrations in mitochondria leading to changes either in mitochondrial content per cell, or in mitochondrial functional capacity (i....

journal_title：Biological psychiatry

authors： Picard M,Prather AA,Puterman E,Cuillerier A,Coccia M,Aschbacher K,Burelle Y,Epel ES

更新日期：2018-07-01 00:00:00

abstract：:Sleep homeostasis and circadian function are important maintaining factors for optimal health and well-being. Conversely, sleep and circadian disruptions are implicated in a variety of adverse health outcomes, including substance use disorders. These risks are particularly salient during adolescence. Adolescents requi...

journal_title：Biological psychiatry

authors： Logan RW,Hasler BP,Forbes EE,Franzen PL,Torregrossa MM,Huang YH,Buysse DJ,Clark DB,McClung CA

更新日期：2018-06-15 00:00:00

abstract：:Athina Markou and others argue forcefully for the adoption of a "translational-back translational strategy" for central nervous system drug discovery involving novel application of drugs with established safety profiles in proof-of-principle studies in humans, which in turn encourage parallel studies using experimenta...

journal_title：Biological psychiatry

authors： Phillips AG,Geyer MA,Robbins TW

更新日期：2018-06-01 00:00:00

abstract：:Parental stress exposures are implicated in the risk for offspring neurodevelopmental and neuropsychiatric disorders, prompting critical examination of preconception and prenatal periods as vulnerable to environmental insults such as stress. Evidence from human studies and animal models demonstrates the influence that...

journal_title：Biological psychiatry

authors： Chan JC,Nugent BM,Bale TL

更新日期：2018-05-15 00:00:00

abstract：:There has been an explosion of interest in the study of microorganisms inhabiting the gastrointestinal tract (gut microbiota) and their impact on host health and physiology. Accumulating data suggest that altered communication between gut microbiota and host systems could participate in disorders such as obesity, diab...

journal_title：Biological psychiatry

authors： Bruce-Keller AJ,Salbaum JM,Berthoud HR

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (TMS) therapy can modulate pathological neural network functional connectivity in major depressive disorder (MDD). Posttraumatic stress disorder is often comorbid with MDD, and symptoms of both disorders can be alleviated with TMS therapy. This is the first study ...

journal_title：Biological psychiatry

authors： Philip NS,Barredo J,van 't Wout-Frank M,Tyrka AR,Price LH,Carpenter LL

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety- and depressive-like behaviors. Concomitantly, microglia in the PFC undergo morphological and functional changes following stress exposure, suggesting that micro...

journal_title：Biological psychiatry

authors： Wohleb ES,Terwilliger R,Duman CH,Duman RS

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Current neuroimaging perspectives on a variety of mental disorders emphasize dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the regulation of social cognition and behavior, accumulates in cerebrospinal fluid after intranasal administration in macaques and humans and modulates...

journal_title：Biological psychiatry

authors： Spengler FB,Schultz J,Scheele D,Essel M,Maier W,Heinrichs M,Hurlemann R

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:A recent analysis of 25 historical candidate gene polymorphisms for schizophrenia in the largest genome-wide association study conducted to date suggested that these commonly studied variants were no more associated with the disorder than would be expected by chance. However, the same study identified other ...

journal_title：Biological psychiatry

authors： Johnson EC,Border R,Melroy-Greif WE,de Leeuw CA,Ehringer MA,Keller MC

更新日期：2017-11-15 00:00:00

abstract：BACKGROUND:Emerging evidence suggests disruptions in the wiring organization of the brain's network in schizophrenia (SZ) and bipolar disorder (BD). As the importance of genetic predisposition has been firmly established in these illnesses, children (offspring) of patients constitute an at-risk population. This study e...

journal_title：Biological psychiatry

authors： Collin G,Scholtens LH,Kahn RS,Hillegers MHJ,van den Heuvel MP

更新日期：2017-11-15 00:00:00

abstract：BACKGROUND:Eye movement desensitization and reprocessing (EMDR) is an effective treatment for posttraumatic stress disorder. During EMDR, patients make horizontal eye movements (EMs) while simultaneously recalling a traumatic memory, which renders the memory less vivid and emotional when it is later recalled again. Rec...

journal_title：Biological psychiatry

authors： Littel M,Kenemans JL,Baas JMP,Logemann HNA,Rijken N,Remijn M,Hassink RJ,Engelhard IM,van den Hout MA

更新日期：2017-10-15 00:00:00

abstract：BACKGROUND:Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop th...

journal_title：Biological psychiatry

authors： Bronson SL,Chan JC,Bale TL

更新日期：2017-07-15 00:00:00

abstract：BACKGROUND:Chromosome 22q11.2 deletion syndrome (22q11DS) is a promising model for studying psychosis risk. Direct comparisons of psychosis features between 22q11DS and nondeleted (ND) individuals are limited by inconsistency and small samples. In the largest study to date, we compare 22q11DS to ND in comorbidities, fu...

journal_title：Biological psychiatry

authors： Tang SX,Moore TM,Calkins ME,Yi JJ,Savitt A,Kohler CG,Souders MC,Zackai EH,McDonald-McGinn DM,Emanuel BS,Gur RC,Gur RE

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The schizophrenia-associated BRD1 gene encodes a transcriptional regulator whose comprehensive chromatin interactome is enriched with schizophrenia risk genes. However, the biology underlying the disease association of BRD1 remains speculative. METHODS:This study assessed the transcriptional drive of a schi...

journal_title：Biological psychiatry

authors： Qvist P,Christensen JH,Vardya I,Rajkumar AP,Mørk A,Paternoster V,Füchtbauer EM,Pallesen J,Fryland T,Dyrvig M,Hauberg ME,Lundsberg B,Fejgin K,Nyegaard M,Jensen K,Nyengaard JR,Mors O,Didriksen M,Børglum AD

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Anxiety disorders are associated with disruptions in both emotional processing and decision making. As a result, anxious individuals often make decisions that favor harm avoidance. However, this bias could be driven by enhanced aversion to uncertainty about the decision outcome (e.g., risk) or aversion to ne...

journal_title：Biological psychiatry

authors： Charpentier CJ,Aylward J,Roiser JP,Robinson OJ

更新日期：2017-06-15 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) is characterized by a dysregulation of affect and impaired integration of emotion with cognition. These traits are also expressed in probands at high genetic risk of BD. The inferior frontal gyrus (IFG) is a key cortical hub in the circuits of emotion and cognitive control, and it has b...

journal_title：Biological psychiatry

authors： Roberts G,Lord A,Frankland A,Wright A,Lau P,Levy F,Lenroot RK,Mitchell PB,Breakspear M

更新日期：2017-04-15 00:00:00

abstract：BACKGROUND:Addiction relies on persistent alterations of neuronal properties, which depends on gene regulation. Activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying learning and memory. Its role in cocaine-induced neuronal and behavioral adapt...

journal_title：Biological psychiatry

authors： Salery M,Dos Santos M,Saint-Jour E,Moumné L,Pagès C,Kappès V,Parnaudeau S,Caboche J,Vanhoutte P

更新日期：2017-04-01 00:00:00

abstract：:The male bias in autism spectrum disorder incidence is among the most extreme of all neuropsychiatric disorders, yet the origins of the sex difference remain obscure. Developmentally, males are exposed to high levels of testosterone and its byproduct, estradiol. Together these steroids modify the course of brain devel...

journal_title：Biological psychiatry

authors： McCarthy MM,Wright CL

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Prenatal inflammatory mechanisms may play a role in the pathogenesis of psychiatric disorders and could be relevant for attention-deficit/hyperactivity disorder (ADHD). We investigated maternal chronic somatic diseases with immune components as possible risk factors for ADHD in offspring. METHODS:We perform...

journal_title：Biological psychiatry

authors： Instanes JT,Halmøy A,Engeland A,Haavik J,Furu K,Klungsøyr K

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:There is well-known heterogeneity in affective mechanisms in depression that may extend to positive affect. We used data-driven parsing of neural connectivity to reveal subgroups present across depressed and healthy individuals during positive processing, informing targets for mechanistic intervention. METH...

journal_title：Biological psychiatry

authors： Price RB,Lane S,Gates K,Kraynak TE,Horner MS,Thase ME,Siegle GJ

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:Limited successes of gene finding for major depressive disorder (MDD) may be partly due to phenotypic heterogeneity. We tested whether the genetic load for MDD, bipolar disorder, and schizophrenia (SCZ) is increased in phenotypically more homogenous MDD patients identified by specific clinical characteristic...

journal_title：Biological psychiatry

authors： Verduijn J,Milaneschi Y,Peyrot WJ,Hottenga JJ,Abdellaoui A,de Geus EJC,Smit JH,Breen G,Lewis CM,Boomsma DI,Beekman ATF,Penninx BWJH

更新日期：2017-02-15 00:00:00

abstract：BACKGROUND:Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated with reduced so...

journal_title：Biological psychiatry

authors： Swartz JR,Waller R,Bogdan R,Knodt AR,Sabhlok A,Hyde LW,Hariri AR

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Fine motor skill impairments are common in autism spectrum disorder (ASD), significantly affecting quality of life. Sensory inputs reaching the primary motor cortex (M1) from the somatosensory cortex (S1) are likely involved in fine motor skill and specifically motor learning. However, the role of these conn...

journal_title：Biological psychiatry

authors： Thompson A,Murphy D,Dell'Acqua F,Ecker C,McAlonan G,Howells H,Baron-Cohen S,Lai MC,Lombardo MV,MRC AIMS Consortium, and Marco Catani.

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Insomnia symptoms are associated with vulnerability to age-related morbidity and mortality. Cross-sectional data suggest that accelerated biological aging may be a mechanism through which sleep influences risk. A novel method for determining age acceleration using epigenetic methylation to DNA has demonstrat...

journal_title：Biological psychiatry

authors： Carroll JE,Irwin MR,Levine M,Seeman TE,Absher D,Assimes T,Horvath S

更新日期：2017-01-15 00:00:00

abstract：BACKGROUND:Recent genome-wide association studies have identified genetic loci that jointly make a considerable contribution to risk of developing Alzheimer's disease (AD). Because neuropathological features of AD can be present several decades before disease onset, we investigated whether effects of polygenic risk are...

journal_title：Biological psychiatry

authors： Foley SF,Tansey KE,Caseras X,Lancaster T,Bracht T,Parker G,Hall J,Williams J,Linden DE

更新日期：2017-01-15 00:00:00

abstract：BACKGROUND:Perinatal maternal depression is a serious health concern with potential lasting negative consequences for children. Prenatal depression is associated with altered brain gray matter in children, though relations between postpartum depression and children's brains and the role of white matter are unclear. ME...

journal_title：Biological psychiatry

authors： Lebel C,Walton M,Letourneau N,Giesbrecht GF,Kaplan BJ,Dewey D

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Major depressive disorder is associated with disturbed circadian rhythms. To investigate the causal relationship between mood disorders and circadian clock disruption, previous studies in animal models have employed light/dark manipulations, global mutations of clock genes, or brain area lesions. However, li...

journal_title：Biological psychiatry

authors： Landgraf D,Long JE,Proulx CD,Barandas R,Malinow R,Welsh DK

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Multiple neuropsychiatric disorders, e.g., depression, are linked to imbalances in excitatory and inhibitory neurotransmission and prefrontal cortical dysfunction, and are concomitant with chronic stress. METHODS:We used electrophysiologic (n = 5-6 animals, 21-25 cells/group), neuroanatomic (n = 6-8/group),...

journal_title：Biological psychiatry

authors： McKlveen JM,Morano RL,Fitzgerald M,Zoubovsky S,Cassella SN,Scheimann JR,Ghosal S,Mahbod P,Packard BA,Myers B,Baccei ML,Herman JP

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND:The medial prefrontal cortex (mPFC) subserves complex cognition and is impaired by stress. Corticotropin-releasing factor (CRF), through CRF receptor 1 (CRFR1), constitutes a key element of the stress response. However, its contribution to the effects of stress in the mPFC remains unclear. METHODS:Mice were...

journal_title：Biological psychiatry

authors： Uribe-Mariño A,Gassen NC,Wiesbeck MF,Balsevich G,Santarelli S,Solfrank B,Dournes C,Fries GR,Masana M,Labermeier C,Wang XD,Hafner K,Schmid B,Rein T,Chen A,Deussing JM,Schmidt MV

更新日期：2016-11-15 00:00:00